Drug Discovery

About this course: The University of California San Diego, Skaggs School of Pharmacy and Pharmaceutical Sciences Drug Discovery course brings you lectures from both faculty and industry experts. With this course, recorded on campus at UCSD, we seek to share our access to top people in the field who bring an unprecedented range of expertise on drug discovery. In this course you will learn the drug discovery process up to the filing of an Initial New Drug Application or IND. Each week you will learn the steps that a pharmaceutical or biotech company goes through to discover a new therapeutic drug. In this course you will be able to: * Understand the pharmaceutical and biotechnology market a changing landscape * Learn the major aspects of the drug discovery process, starting with target selection, to compound screening to designing lead candidates. * Recognize current modern drug discovery based on the lock-and-key theory, which attempts to use one single compound to hit one target to combat the related disease. * Increase understanding of the various drug discovery tools and methods that are used for finding, identifying and designing a new drug. * Define and understand the regulatory responsibilities for drug discovery to file an Investigational New Drug Application (IND). This course is intended as part 1 of a series: Drug Discovery, Drug Development (https://www.coursera.org/learn/drug-development) and Drug Commercialization (https://www.coursera.org/learn/drug-commercialization). We would highly recommend that you take the courses in order since it will give you a better understanding on how a drug is discovered in the lab before being tested in clinical trials and then launched in the market place.

Who is this class for: This class is for professionals and students interested in better understanding the process of drug discovery in the pharmaceutical and biotech industry as well as anyone who wants to learn how new drugs are discovered.

Created by:  University of California, San Diego

• Taught by:  Williams S. Ettouati, Pharm.D., Director, Industrial Relations & Development; Health Sciences Associate Clinical Professor, N.S.

  Skaggs School of Pharmacy and Pharmaceutical Sciences

• Taught by:  Joseph D. Ma, Associate Professor of Clinical Pharmacy

  Skaggs School of Pharmacy and Pharmaceutical Sciences

Level Beginner Commitment 3-4 hours/week Language English How To Pass Pass all graded assignments to complete the course. User Ratings 4.6 stars Average User Rating 4.6See what learners said Coursework

Each course is like an interactive textbook, featuring pre-recorded videos, quizzes and projects.

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University of California, San Diego UC San Diego is an academic powerhouse and economic engine, recognized as one of the top 10 public universities by U.S. News and World Report. Innovation is central to who we are and what we do. Here, students learn that knowledge isn't just acquired in the classroom—life is their laboratory.

Syllabus


WEEK 1


Welcome!



1 video expand

1. Video: Welcome!
2. Discussion Prompt: Get to know your fellow Courserians!

Pharmaceutical & Biotechnology Industry Landscape
In this module course lead Dr. Williams Ettouati begins by giving a landscape overview of the Pharma and Biotechnology landscape.


7 videos, 3 readings expand

1. Video: Pharma and Biotechnology Landscape
2. Video: Key Issues for Pharma
3. Video: Global Outlook: What will the Future Look Like?
4. Discussion Prompt: Mega-mergers: What are their implications?
5. Video: Creating a Sustainable Business
6. Reading: Meet the Instructors
7. Video: Patient-Centric Drug Discovery and Commercialization
8. Video: A New Approach to R&D
9. Video: Innovation and Its Role in Developing Better Drugs
10. Discussion Prompt: Pharma and Biotech Changes
11. Reading: Lecture Slides
12. Reading: A new Master Degree in Science in Drug Development & Product Management at UCSD

Graded: Pharma and Biotech

WEEK 2


Drug Discovery: Proteomics, Genomics



This week we will be hearing from Phillip Bourne, PhD. Dr. Bourne was, at the time of this recording, the Associate Vice Chancellor for Innovation and Industrial Alliances in the UCSD Skaggs School of Pharmacy and Pharmaceutical Sciences. Since that time, he has been named the first Associate Director for Data Science at the United States National Institutes of Health.


5 videos, 1 reading expand

1. Video: Drug Discovery: Proteomics, Genomics I
2. Video: Drug Discovery: Proteomics, Genomics II
3. Video: Drug Discovery: Proteomics, Genomics III
4. Video: Drug Discovery: Proteomics, Genomics IV
5. Video: Drug Discovery: Proteomics, Genomics V
6. Discussion Prompt: What's the most interesting thing discussed this module?
7. Reading: Lecture Slides

Graded: Drug Discovery: Proteomics, Genomics

Compound Selection & Preclinical Studies
This week we will hear from Ronald Christopher, Ph.D. Dr. Ronald Christopher, Vice President of Preclinical Trials at Arena Pharmaceuticals.


6 videos, 1 reading expand

1. Video: Compound Selection & Preclinical Studies I
2. Video: Compound Selection & Preclinical Studies II
3. Video: Compound Selection & Preclinical Studies III
4. Discussion Prompt: Efforts in Drug Discovery: Differences between first-in-class and best-in-class
5. Video: Compound Selection & Preclinical Studies IV
6. Video: Compound Selection & Preclinical Studies V
7. Video: Compound Selection & Preclinical Studies VI
8. Discussion Prompt: Develop your own first-in-class drug
9. Reading: Lecture Slides

Graded: Compound Selection and Pre-clinical Studies

WEEK 3


Challenges in Fragment Based Drug Discovery for Protein Kinases



In this module we will hear from Stephen Burley, M.D., Ph.D. At the time of this recording, Director of the Center for Integrative Proteomics at Rutgers University. He is now the Director of the Protein Data Bank and remains an Adjunct Professor at the UCSD Skaggs School of Pharmacy and Pharmaceutical Sciences.


5 videos, 2 readings expand

1. Video: Challenges in Fragment Based Drug Discovery for Protein Kinases I
2. Video: Challenges in Fragment Based Drug Discovery for Protein Kinases II
3. Video: Challenges in Fragment Based Drug Discovery for Protein Kinases III
4. Discussion Prompt: Collaboration among scientific disciplines - how important is it?
5. Video: Challenges in Fragment Based Drug Discovery for Protein Kinases IV
6. Video: Challenges in Fragment Based Drug Discovery for Protein Kinases V
7. Discussion Prompt: Clinical Trials Interruptions: What can we learn?
8. Reading: Optional: Examples using structure based approaches
9. Reading: Lecture Slides

Graded: Challenges in Fragment Based Drug Discovery for Protein Kinases

Key Concepts in Drug Delivery
This module we hear from Professor of Clinical Pharmacy and Pediatrics, Brookie Best, Pharm. D., of UCSD's Skaggs School of Pharmacy and Pharmaceutical Sciences.


5 videos, 1 reading expand

1. Video: Key Concepts in Drug Delivery I
2. Video: Key Concepts in Drug Delivery II
3. Video: Key Concepts in Drug Delivery III
4. Video: Key Concepts in Drug Delivery IV
5. Video: Key Concepts in Drug Delivery V
6. Reading: Lecture Slides
7. Discussion Prompt: How did this course help you?

Graded: Concepts in Drug Delivery Quiz